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SENP3 facilitates M1 macrophage polarization via the HIF-1α/PKM2 axis in lipopolysaccharide-induced acute lung injury

M1/M2 macrophage polarization plays a pivotal role in the development of acute lung injury (ALI). The hypoxia-inducible factor-1α/pyruvate kinase M2 (HIF-1α/PKM2) axis, which functions upstream of macrophage polarization, has been implicated in this process. The function of HIF-1α is known to be tig...

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Detalles Bibliográficos
Autores principales: He, Shuangjun, Fan, Chenyu, Ji, Yiming, Su, Qian, Zhao, Feng, Xie, Cuiying, Chen, Xuelian, Zhang, Yang, Chen, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164277/
https://www.ncbi.nlm.nih.gov/pubmed/37016838
http://dx.doi.org/10.1177/17534259231166212