Cargando…

SENP3 facilitates M1 macrophage polarization via the HIF-1α/PKM2 axis in lipopolysaccharide-induced acute lung injury

M1/M2 macrophage polarization plays a pivotal role in the development of acute lung injury (ALI). The hypoxia-inducible factor-1α/pyruvate kinase M2 (HIF-1α/PKM2) axis, which functions upstream of macrophage polarization, has been implicated in this process. The function of HIF-1α is known to be tig...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Shuangjun, Fan, Chenyu, Ji, Yiming, Su, Qian, Zhao, Feng, Xie, Cuiying, Chen, Xuelian, Zhang, Yang, Chen, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2023
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164277/ https://www.ncbi.nlm.nih.gov/pubmed/37016838 http://dx.doi.org/10.1177/17534259231166212

Ejemplares similares

SENP3 in monocytes/macrophages up‐regulates tissue factor and mediates lipopolysaccharide‐induced acute lung injury by enhancing JNK phosphorylation
por: Chen, Xuelian, et al.
Publicado: (2020)

SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop
por: Cui, Chun-Ping, et al.
Publicado: (2017)

SENP1 Interacts with HIF1α to Regulate Glycolysis of Prostatic Carcinoma Cells
por: Wang, Chunyang, et al.
Publicado: (2019)

The role of the HIF‐1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer
por: Wang, Jing‐Zi, et al.
Publicado: (2021)

The effect of HIF-1α and PKM1 expression on acquisition of chemoresistance
por: Okazaki, Mitsuyoshi, et al.
Publicado: (2018)

Expression of HIF-1α/PKM2 axis correlates to biological and clinical significance in papillary thyroid carcinoma
por: Hao, Zengfang, et al.
Publicado: (2023)

SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α
por: Ao, Qilin, et al.
Publicado: (2015)

Knockdown of SENP1 inhibits HIF-1α SUMOylation and suppresses oncogenic CCNE1 in Wilms tumor
por: Zhu, Shibo, et al.
Publicado: (2021)

PKM2, STAT3 and HIF-1α: The Warburg’s vicious circle
por: Demaria, Marco, et al.
Publicado: (2012)

PKM2 and HIF-1α regulation in prostate cancer cell lines
por: Hasan, Diya, et al.
Publicado: (2018)

Human cytomegalovirus encoded chemokine receptor US28 activates the HIF-1α/PKM2 axis in glioblastoma cells
por: de Wit, Raymond H., et al.
Publicado: (2016)

SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response
por: Du, Shi-chun, et al.
Publicado: (2019)

Discovery of a Dual SENP1 and SENP2 Inhibitor
por: Brand, Michael, et al.
Publicado: (2022)

SENP3 loss promotes M2 macrophage polarization and breast cancer progression
por: Xiao, Ming, et al.
Publicado: (2021)

SENP1 and SENP2 regulate SUMOylation of amyloid precursor protein
por: Maruyama, Takuma, et al.
Publicado: (2018)

SENP1 and SENP2 affect spatial and temporal control of sumoylation in mitosis
por: Cubeñas-Potts, Caelin, et al.
Publicado: (2013)

Lactylation of PKM2 Suppresses Inflammatory Metabolic Adaptation in Pro-inflammatory Macrophages
por: Wang, Jizhuang, et al.
Publicado: (2022)

The SUMO protease SENP1 promotes aggressive behaviors of high HIF2α expressing renal cell carcinoma cells
por: Lee, Moon Hee, et al.
Publicado: (2022)

Effects of IRF1 and IFN-β interaction on the M1 polarization of macrophages and its antitumor function
por: XIE, CHANGLI, et al.
Publicado: (2016)

Iridin Prevented Against Lipopolysaccharide-Induced Inflammatory Responses of Macrophages via Inactivation of PKM2-Mediated Glycolytic Pathways
por: Ying, Zhen-Hua, et al.
Publicado: (2021)

Impact of Platelet Transfusion Thresholds on Outcomes of Patients With Sepsis: Analysis of the MIMIC-IV Database
por: Zhou, Wei, et al.
Publicado: (2022)

PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation
por: Azoitei, Ninel, et al.
Publicado: (2016)

Leptin regulation of the p53-HIF1α/PKM2-aromatase axis in breast adipose stromal cells – a novel mechanism for the obesity-breast cancer link
por: Zahid, Heba, et al.
Publicado: (2017)

Renoprotection of Microcystin-RR in Unilateral Ureteral Obstruction-Induced Renal Fibrosis: Targeting the PKM2-HIF-1α Pathway
por: Ren, Yan, et al.
Publicado: (2022)

Genetic Polymorphism of SUMO-Specific Cysteine Proteases − SENP1 and SENP2 in Breast Cancer
por: Mirecka, Alicja, et al.
Publicado: (2016)

Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages
por: Williams, Niamh C., et al.
Publicado: (2021)

Metformin Inhibits Epithelial-to-Mesenchymal Transition of Keloid Fibroblasts via the HIF-1α/PKM2 Signaling Pathway
por: Lei, Rui, et al.
Publicado: (2019)

The HIF-1α/LC3-II Axis Impacts Fungal Immunity in Human Macrophages
por: Friedrich, Dirk, et al.
Publicado: (2019)

DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages
por: Lao, Yimin, et al.
Publicado: (2018)

Two distinct sites in Nup153 mediate interaction with the SUMO proteases SENP1 and SENP2
por: Chow, Kin-Hoe, et al.
Publicado: (2012)

Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2/HIF-1α axis
por: Hua, Qian, et al.
Publicado: (2020)

Btk Regulates Macrophage Polarization in Response to Lipopolysaccharide
por: Ní Gabhann, Joan, et al.
Publicado: (2014)

Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis
por: Feng, Jiao, et al.
Publicado: (2020)

Performance of Procalcitonin to Distinguish Fungal from Bacterial Infections in Patients with Systemic Lupus Erythematosus
por: He, Shuangjun, et al.
Publicado: (2021)

PRMT5 facilitates angiogenesis and EMT via HIF-1α/VEGFR/Akt signaling axis in lung cancer
por: Zheng, Yonghua, et al.
Publicado: (2023)

SENP3 Aggravates Renal Tubular Epithelial Cell Apoptosis in Lipopolysaccharide-Induced Acute Kidney Injury via deSUMOylation of Drp1
por: Wang, Lirui, et al.
Publicado: (2022)

HIF-1α-Overexpressing Mesenchymal Stem Cells Attenuate Colitis by Regulating M1-like Macrophages Polarization toward M2-like Macrophages
por: Zhu, Wenya, et al.
Publicado: (2023)

SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death
por: Guo, Chun, et al.
Publicado: (2017)

Overexpressed PKM2 promotes macrophage phagocytosis and atherosclerosis
por: Gai, Xiaochen, et al.
Publicado: (2022)

Loss of SENP3 mediated the formation of nasal polyps in nasal mucosal inflammation by increasing alternative activated macrophage
por: Bao, Ximing, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_m65ams1lcqndlnjrh236qfkaip