Goldilocks and RNA: where Mg(2+) concentration is just right

Magnesium, the most abundant divalent cation in cells, catalyzes RNA cleavage but also promotes RNA folding. Because folding can protect RNA from cleavage, we predicted a ‘Goldilocks landscape’, with local maximum in RNA lifetime at Mg(2+) concentrations required for folding. Here, we use simulation...

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Detalles Bibliográficos
Autores principales: Guth-Metzler, Rebecca, Mohamed, Ahmad Mohyeldin, Cowan, Elizabeth T, Henning, Ashleigh, Ito, Chieri, Frenkel-Pinter, Moran, Wartell, Roger M, Glass, Jennifer B, Williams, Loren Dean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164553/
https://www.ncbi.nlm.nih.gov/pubmed/36987860
http://dx.doi.org/10.1093/nar/gkad124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164553/
https://www.ncbi.nlm.nih.gov/pubmed/36987860
http://dx.doi.org/10.1093/nar/gkad124

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