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Goldilocks and RNA: where Mg(2+) concentration is just right
Magnesium, the most abundant divalent cation in cells, catalyzes RNA cleavage but also promotes RNA folding. Because folding can protect RNA from cleavage, we predicted a ‘Goldilocks landscape’, with local maximum in RNA lifetime at Mg(2+) concentrations required for folding. Here, we use simulation...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164553/ https://www.ncbi.nlm.nih.gov/pubmed/36987860 http://dx.doi.org/10.1093/nar/gkad124 |