Localized modulation of DNA supercoiling, triggered by the Shigella anti-silencer VirB, is sufficient to relieve H-NS-mediated silencing

In Bacteria, nucleoid structuring proteins govern nucleoid dynamics and regulate transcription. In Shigella spp., at ≤30°C, the histone-like nucleoid structuring protein (H-NS) transcriptionally silences many genes on the large virulence plasmid. Upon a switch to 37°C, VirB, a DNA binding protein an...

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Detalles Bibliográficos
Autores principales: Picker, Michael A, Karney, Monika M A, Gerson, Taylor M, Karabachev, Alexander D, Duhart, Juan C, McKenna, Joy A, Wing, Helen J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164555/
https://www.ncbi.nlm.nih.gov/pubmed/36794722
http://dx.doi.org/10.1093/nar/gkad088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164555/
https://www.ncbi.nlm.nih.gov/pubmed/36794722
http://dx.doi.org/10.1093/nar/gkad088

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