Specific targeting of plasmids with Argonaute enables genome editing

Prokaryotic Argonautes (pAgos) are programmable nucleases involved in cell defense against invading DNA. In vitro, pAgos can bind small single-stranded guide DNAs to recognize and cleave complementary DNA. In vivo, pAgos preferentially target plasmids, phages and multicopy genetic elements. Here, we...

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Detalles Bibliográficos
Autores principales: Esyunina, Daria, Okhtienko, Anastasiia, Olina, Anna, Panteleev, Vladimir, Prostova, Maria, Aravin, Alexei A, Kulbachinskiy, Andrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164558/
https://www.ncbi.nlm.nih.gov/pubmed/36987855
http://dx.doi.org/10.1093/nar/gkad191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164558/
https://www.ncbi.nlm.nih.gov/pubmed/36987855
http://dx.doi.org/10.1093/nar/gkad191

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