Quantitative haplotype-resolved analysis of mitochondrial DNA heteroplasmy in Human single oocytes, blastoids, and pluripotent stem cells

Maternal mitochondria are the sole source of mtDNA for every cell of the offspring. Heteroplasmic mtDNA mutations inherited from the oocyte are a common cause of metabolic diseases and associated with late-onset diseases. However, the origin and dynamics of mtDNA heteroplasmy remain unclear. We used...

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Detalles Bibliográficos
Autores principales: Bi, Chongwei, Wang, Lin, Fan, Yong, Yuan, Baolei, Alsolami, Samhan, Zhang, Yingzi, Zhang, Pu-Yao, Huang, Yanyi, Yu, Yang, Izpisua Belmonte, Juan Carlos, Li, Mo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164563/
https://www.ncbi.nlm.nih.gov/pubmed/37014011
http://dx.doi.org/10.1093/nar/gkad209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164563/
https://www.ncbi.nlm.nih.gov/pubmed/37014011
http://dx.doi.org/10.1093/nar/gkad209

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