Cargando…

Synergistic binding of actinomycin D and echinomycin to DNA mismatch sites and their combined anti-tumour effects

Combination cancer chemotherapy is one of the most useful treatment methods to achieve a synergistic effect and reduce the toxicity of dosing with a single drug. Here, we use a combination of two well-established anticancer DNA intercalators, actinomycin D (ActD) and echinomycin (Echi), to screen th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Satange, Roshan, Chang, Chih-Chun, Li, Long‐Yuan, Lin, Sheng-Hao, Neidle, Stephen, Hou, Ming-Hon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164580/ https://www.ncbi.nlm.nih.gov/pubmed/36919604 http://dx.doi.org/10.1093/nar/gkad156

Ejemplares similares

Cyclic mismatch binding ligand CMBL4 binds to the 5′-T-3′/5′-GG-3′ site by inducing the flipping out of thymine base
por: Mukherjee, Sanjukta, et al.
Publicado: (2016)

Hg(II) binds to C–T mismatches with high affinity
por: Schmidt, Olivia P, et al.
Publicado: (2018)

Polymorphic G:G mismatches act as hotspots for inducing right-handed Z DNA by DNA intercalation
por: Satange, Roshan, et al.
Publicado: (2019)

Native mass spectrometry provides direct evidence for DNA mismatch-induced regulation of asymmetric nucleotide binding in mismatch repair protein MutS
por: Monti, Maria Chiara, et al.
Publicado: (2011)

Guide-target mismatch effects on dCas9–sgRNA binding activity in living bacterial cells
por: Feng, Huibao, et al.
Publicado: (2021)

The NTP binding site of the polymerase ribozyme
por: Akoopie, Arvin, et al.
Publicado: (2018)

Salt-mediated two-site ligand binding by the cocaine-binding aptamer
por: Neves, Miguel A.D., et al.
Publicado: (2017)

Selective tumor cell death induced by irradiated riboflavin through recognizing DNA G–T mismatch
por: Yuan, Yi, et al.
Publicado: (2017)

Selective alkylation of T–T mismatched DNA using vinyldiaminotriazine–acridine conjugate
por: Onizuka, Kazumitsu, et al.
Publicado: (2018)

Cooperative recognition of T:T mismatch by echinomycin causes structural distortions in DNA duplex
por: Wu, Pei-Ching, et al.
Publicado: (2018)

A survey of recent unusual high-resolution DNA structures provoked by mismatches, repeats and ligand binding
por: Satange, Roshan, et al.
Publicado: (2018)

Synergistic effects of ATP and RNA binding to human DEAD-box protein DDX1
por: Kellner, Julian N., et al.
Publicado: (2015)

Multiple DNA-binding sites in Tetrahymena telomerase
por: Finger, Sharon N., et al.
Publicado: (2008)

New insights into a classic aptamer: binding sites, cooperativity and more sensitive adenosine detection
por: Zhang, Zijie, et al.
Publicado: (2017)

Restriction endonuclease TseI cleaves A:A and T:T mismatches in CAG and CTG repeats
por: Ma, Long, et al.
Publicado: (2013)

Distinct patterns of Cas9 mismatch tolerance in vitro and in vivo
por: Fu, Becky X.H., et al.
Publicado: (2016)

Sequence specificity, energetics and mechanism of mismatch recognition by DNA damage sensing protein Rad4/XPC
por: Panigrahi, Abhinandan, et al.
Publicado: (2020)

Mismatch discrimination and sequence bias during end-joining by DNA ligases
por: Bilotti, Katharina, et al.
Publicado: (2022)

Site-specific replacement of the thymine methyl group by fluorine in thrombin binding aptamer significantly improves structural stability and anticoagulant activity
por: Virgilio, Antonella, et al.
Publicado: (2015)

Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors
por: Saydam, Nurten, et al.
Publicado: (2007)

Two RNA-binding sites in plant fibrillarin provide interactions with various RNA substrates
por: Rakitina, D. V., et al.
Publicado: (2011)

The ribosomal A-site finger is crucial for binding and activation of the stringent factor RelA
por: Kudrin, Pavel, et al.
Publicado: (2018)

DNA binding induces active site conformational change in the human TREX2 3′-exonuclease
por: de Silva, Udesh, et al.
Publicado: (2009)

Kinesin-5 Allosteric Inhibitors Uncouple the Dynamics of Nucleotide, Microtubule, and Neck-Linker Binding Sites
por: Scarabelli, Guido, et al.
Publicado: (2014)

High-fidelity KKH variant of Staphylococcus aureus Cas9 nucleases with improved base mismatch discrimination
por: Yuen, Chaya T L, et al.
Publicado: (2022)

DNA topoisomerase II selects DNA cleavage sites based on reactivity rather than binding affinity
por: Mueller-Planitz, Felix, et al.
Publicado: (2007)

The poor homology stringency in the heteroduplex allows strand exchange to incorporate desirable mismatches without sacrificing recognition in vivo
por: Danilowicz, Claudia, et al.
Publicado: (2015)

Dynamic competition of DsrA and rpoS fragments for the proximal binding site of Hfq as a means for efficient annealing
por: Hwang, Wonseok, et al.
Publicado: (2011)

Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding
por: Serrao, Erik, et al.
Publicado: (2014)

SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity
por: Seamon, Kyle J., et al.
Publicado: (2015)

Site specific target binding controls RNA cleavage efficiency by the Kaposi's sarcoma-associated herpesvirus endonuclease SOX
por: Mendez, Aaron S, et al.
Publicado: (2018)

Structural and biochemical insight into the mechanism of dual CpG site binding and methylation by the DNMT3A DNA methyltransferase
por: Emperle, Max, et al.
Publicado: (2021)

A strand-passage conformation of DNA gyrase is required to allow the bacterial toxin, CcdB, to access its binding site
por: Smith, Andrew B., et al.
Publicado: (2006)

Noncanonical substrate preference of lambda exonuclease for 5′-nonphosphate-ended dsDNA and a mismatch-induced acceleration effect on the enzymatic reaction
por: Wu, Tongbo, et al.
Publicado: (2018)

Decoupling the bridge helix of Cas12a results in a reduced trimming activity, increased mismatch sensitivity and impaired conformational transitions
por: Wörle, Elisabeth, et al.
Publicado: (2021)

A phosphate-targeted dinuclear Cu(II) complex combining major groove binding and oxidative DNA cleavage
por: Molphy, Zara, et al.
Publicado: (2018)

Binding of cellular nucleolin with the viral core RNA G-quadruplex structure suppresses HCV replication
por: Bian, Wen-Xiu, et al.
Publicado: (2019)

Inhibition of Mg(2+) binding and DNA religation by bacterial topoisomerase I via introduction of an additional positive charge into the active site region
por: Sorokin, Elena P., et al.
Publicado: (2008)

The interaction of Pcf11 and Clp1 is needed for mRNA 3′-end formation and is modulated by amino acids in the ATP-binding site
por: Ghazy, Mohamed A., et al.
Publicado: (2012)

BMPQ-1 binds selectively to (3+1) hybrid topologies in human telomeric G-quadruplex multimers
por: Gao, Chao, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_cs6k6hnsu347di8q90bj34ei3d