Piezo1 induces endothelial responses to shear stress via soluble adenylyl Cyclase-IP(3)R2 circuit

Endothelial cells (ECs) continuously sense and adapt to changes in shear stress generated by blood flow. Here, we show that the activation of the mechanosensitive channel Piezo1 by defined shear forces induces Ca(2+) entry into the endoplasmic reticulum (ER) via the ER Ca(2+) ATPase pump. This entry...

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Detalles Bibliográficos
Autores principales: Santana Nunez, Dianicha, Malik, Asrar B., Lee, Quinn, Ahn, Sang Joon, Coctecon-Murillo, Arnold, Lazarko, Dana, Levitan, Irena, Mehta, Dolly, Komarova, Yulia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164902/
https://www.ncbi.nlm.nih.gov/pubmed/37168565
http://dx.doi.org/10.1016/j.isci.2023.106661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164902/
https://www.ncbi.nlm.nih.gov/pubmed/37168565
http://dx.doi.org/10.1016/j.isci.2023.106661

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