The stem cell–supporting small molecule UM171 triggers Cul3-KBTBD4–mediated degradation of ELM2 domain–harboring proteins

To chemically modulate the ubiquitin-proteasome system for the degradation of specific target proteins is currently emerging as an alternative therapeutic modality. Earlier, we discovered such properties of the stem cell–supporting small molecule UM171 and identified that members of the CoREST compl...

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Detalles Bibliográficos
Autores principales: Žemaitis, Kristijonas, Ghosh, Sudip, Hansson, Jenny, Subramaniam, Agatheeswaran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
JBC Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164905/
https://www.ncbi.nlm.nih.gov/pubmed/36997086
http://dx.doi.org/10.1016/j.jbc.2023.104662

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164905/
https://www.ncbi.nlm.nih.gov/pubmed/36997086
http://dx.doi.org/10.1016/j.jbc.2023.104662

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