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Exploration of O-GlcNAc transferase glycosylation sites reveals a target sequence compositional bias

O-GlcNAc transferase (OGT) is an essential glycosylating enzyme that catalyzes the addition of N-acetylglucosamine to serine or threonine residues of nuclear and cytoplasmic proteins. The enzyme glycosylates a broad range of peptide sequences and the prediction of glycosylation sites has proven chal...

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Detalles Bibliográficos
Autores principales: Chong, P. Andrew, Nosella, Michael L., Vanama, Manasvi, Ruiz-Arduengo, Roxana, Forman-Kay, Julie D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164912/
https://www.ncbi.nlm.nih.gov/pubmed/36963488
http://dx.doi.org/10.1016/j.jbc.2023.104629