Metformin mitigates SASP secretion and LPS-triggered hyper-inflammation in Doxorubicin-induced senescent endothelial cells

Introduction: Doxorubicin (DOX), a chemotherapeutic drug, induces senescence and increases the secretion of senescence-associated secretory phenotype (SASP) in endothelial cells (ECs), which contributes to DOX-induced inflammaging. Metformin, an anti-diabetic drug, demonstrates senomorphic effects o...

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Detalles Bibliográficos
Autores principales: Abdelgawad, Ibrahim Y., Agostinucci, Kevin, Sadaf, Bushra, Grant, Marianne K. O., Zordoky, Beshay N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Aging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164964/
https://www.ncbi.nlm.nih.gov/pubmed/37168843
http://dx.doi.org/10.3389/fragi.2023.1170434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164964/
https://www.ncbi.nlm.nih.gov/pubmed/37168843
http://dx.doi.org/10.3389/fragi.2023.1170434

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