Cargando…

Metformin mitigates SASP secretion and LPS-triggered hyper-inflammation in Doxorubicin-induced senescent endothelial cells

Introduction: Doxorubicin (DOX), a chemotherapeutic drug, induces senescence and increases the secretion of senescence-associated secretory phenotype (SASP) in endothelial cells (ECs), which contributes to DOX-induced inflammaging. Metformin, an anti-diabetic drug, demonstrates senomorphic effects o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abdelgawad, Ibrahim Y., Agostinucci, Kevin, Sadaf, Bushra, Grant, Marianne K. O., Zordoky, Beshay N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Aging
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164964/ https://www.ncbi.nlm.nih.gov/pubmed/37168843 http://dx.doi.org/10.3389/fragi.2023.1170434

Ejemplares similares

EA.hy926 Cells and HUVECs Share Similar Senescence Phenotypes but Respond Differently to the Senolytic Drug ABT-263
por: Abdelgawad, Ibrahim Y., et al.
Publicado: (2022)

Exposure to Doxorubicin Modulates the Cardiac Response to Isoproterenol in Male and Female Mice
por: Agostinucci, Kevin, et al.
Publicado: (2023)

Sexual Dimorphism in Doxorubicin-induced Systemic Inflammation: Implications for Hepatic Cytochrome P450 Regulation
por: Grant, Marianne K.O., et al.
Publicado: (2020)

Divergent Cardiac Effects of Angiotensin II and Isoproterenol Following Juvenile Exposure to Doxorubicin
por: Agostinucci, Kevin, et al.
Publicado: (2022)

Doxorubicin Paradoxically Ameliorates Tumor-Induced Inflammation in Young Mice
por: Abdelgawad, Ibrahim Y., et al.
Publicado: (2021)

Sexual dimorphism of acute doxorubicin-induced nephrotoxicity in C57Bl/6 mice
por: Grant, Marianne K. O., et al.
Publicado: (2019)

Leveraging the Cardio-Protective and Anticancer Properties of Resveratrol in Cardio-Oncology
por: Abdelgawad, Ibrahim Y., et al.
Publicado: (2019)

Dissecting cellular senescence and SASP in Drosophila
por: Ito, Takao, et al.
Publicado: (2016)

Senescence and the SASP: many therapeutic avenues
por: Birch, Jodie, et al.
Publicado: (2020)

Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells
por: Prattichizzo, Francesco, et al.
Publicado: (2016)

Sex-dependent alteration of cardiac cytochrome P450 gene expression by doxorubicin in C57Bl/6 mice
por: Grant, Marianne K. O., et al.
Publicado: (2017)

Senescence utilises inflammatory caspases to drive SASP
por: Wiggins, Kimberley A., et al.
Publicado: (2019)

Senescence and Cancer: Role of Nitric Oxide (NO) in SASP
por: Mabrouk, Nesrine, et al.
Publicado: (2020)

Biliary Epithelial Senescence in Liver Disease: There Will Be SASP
por: Meadows, Vik, et al.
Publicado: (2021)

Whole Chromosome Instability induces senescence and promotes SASP
por: Andriani, Grasiella Angelina, et al.
Publicado: (2016)

Lack of sexual dimorphism in a mouse model of isoproterenol-induced cardiac dysfunction
por: Grant, Marianne K. O., et al.
Publicado: (2020)

“Social Life” of Senescent Cells: What Is SASP and Why Study It?
por: Borodkina, A. V., et al.
Publicado: (2018)

Identification of new candidate biomarkers to support doxorubicin treatments in canine cancer patients
por: Walters, Kristine, et al.
Publicado: (2021)

Immune Senescence, Immunosenescence and Aging
por: Lee, Kyoo-A, et al.
Publicado: (2022)

Anthracycline-induced cardiotoxicity and senescence
por: Booth, Laura K., et al.
Publicado: (2022)

Cellular Senescence and Ageing: Mechanisms and Interventions
por: Mylonas, Andreas, et al.
Publicado: (2022)

Staphylococcus aureus phagocytosis is affected by senescence
por: Robledo, Esteban, et al.
Publicado: (2023)

CYP1B1 as a therapeutic target in cardio-oncology
por: Carrera, Alexa N., et al.
Publicado: (2020)

Sensitive Detection and Monitoring of Senescence-Associated Secretory Phenotype by SASP-RAP Assay
por: Gu, Liubao, et al.
Publicado: (2012)

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells
por: Takahashi, Akiko, et al.
Publicado: (2018)

ROCK inhibition modulates the senescence‐associated secretory phenotype (SASP) in oral keratinocytes
por: Niklander, Sven, et al.
Publicado: (2020)

The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis?
por: Ohtani, Naoko
Publicado: (2022)

Apoptotic stress causes mtDNA release during senescence and drives the SASP
por: Victorelli, Stella, et al.
Publicado: (2023)

Simple Detection Methods for Senescent Cells: Opportunities and Challenges
por: Faragher, Richard G. A.
Publicado: (2021)

Induction of T Cell Senescence by Cytokine Induced Bystander Activation
por: Abbas, Attiya A., et al.
Publicado: (2021)

Inflammation, Immune Senescence, and Dysregulated Immune Regulation in the Elderly
por: Shive, Carey, et al.
Publicado: (2022)

DASS/SASP Workshop
por: Iqbal, M J, et al.
Publicado: (1986)

Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases
por: Blokland, Kaj E.C., et al.
Publicado: (2020)

Editorial: The Impact of Immunosenescence and Senescence of Immune Cells on Responses to Infection and Vaccination
por: Agrawal, Anshu, et al.
Publicado: (2022)

Regucalcin ameliorates doxorubicin-induced cytotoxicity in Cos-7 kidney cells and translocates from the nucleus to the mitochondria
por: Mohammed, Noor A., et al.
Publicado: (2022)

Senescent Endothelial Cells Sustain Their Senescence-Associated Secretory Phenotype (SASP) through Enhanced Fatty Acid Oxidation
por: Giuliani, Angelica, et al.
Publicado: (2023)

Metformin Attenuates Inflammatory Responses and Enhances Antibody Production in an Acute Pneumonia Model of Streptococcus pneumoniae
por: Lee, Grace C., et al.
Publicado: (2022)

Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models
por: Inci, Nurcan, et al.
Publicado: (2022)

HMGB1 coordinates SASP‐related chromatin folding and RNA homeostasis on the path to senescence
por: Sofiadis, Konstantinos, et al.
Publicado: (2021)

Cellular senescence with SASP in periodontal ligament cells triggers inflammation in aging periodontal tissue
por: Ikegami, Kuniko, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ganpfnti2ij8devkeudatftq51