TRIM28 negatively regulates the RLR signaling pathway by targeting MAVS for degradation via K48-linked polyubiquitination

Mitochondrial antiviral signaling (MAVS) protein is a core signaling adapter in the retinoid acid–inducible gene-I–like receptor (RLR) signaling pathway that recruits downstream signaling factors, ultimately leading to the activation of type Ⅰ interferons. However, the mechanisms that modulate the R...

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Detalles Bibliográficos
Autores principales: Chen, Ya-Yun, Ran, Xiang-Hong, Ni, Run-Ze, Mu, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165269/
https://www.ncbi.nlm.nih.gov/pubmed/37119745
http://dx.doi.org/10.1016/j.jbc.2023.104660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165269/
https://www.ncbi.nlm.nih.gov/pubmed/37119745
http://dx.doi.org/10.1016/j.jbc.2023.104660

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