Brain p3‐Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β‐peptide

We propose a new therapeutic strategy for Alzheimer's disease (AD). Brain peptide p3‐Alcβ37 is generated from the neuronal protein alcadein β through cleavage of γ‐secretase, similar to the generation of amyloid β (Aβ) derived from Aβ‐protein precursor/APP. Neurotoxicity by Aβ oligomers (Aβo) i...

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Detalles Bibliográficos
Autores principales: Hata, Saori, Saito, Haruka, Kakiuchi, Takeharu, Fukumoto, Dai, Yamamoto, Shigeyuki, Kasuga, Kensaku, Kimura, Ayano, Moteki, Koichi, Abe, Ruriko, Adachi, Shungo, Kinoshita, Shoich, Yoshizawa‐Kumagaye, Kumiko, Nishio, Hideki, Saito, Takashi, Saido, Takaomi C, Yamamoto, Tohru, Nishimura, Masaki, Taru, Hidenori, Sobu, Yuriko, Ohba, Hiroyuki, Nishiyama, Shingo, Harada, Norihiro, Ikeuchi, Takeshi, Tsukada, Hideo, Ouchi, Yasuomi, Suzuki, Toshiharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165357/
https://www.ncbi.nlm.nih.gov/pubmed/36994913
http://dx.doi.org/10.15252/emmm.202217052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165357/
https://www.ncbi.nlm.nih.gov/pubmed/36994913
http://dx.doi.org/10.15252/emmm.202217052

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