Cargando…
A protocol to study three-dimensional genome structure in individual mutant preimplantation mouse embryos
Hi-C studies the three-dimensional structure of the genome by detecting genome-wide chromatin regions that are in spatial proximity within the nucleus. We developed single-blastocyst Hi-C in mutant mouse embryos to genotype them on sequence. We describe steps for embryo fixation and nuclei permeabil...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165443/ https://www.ncbi.nlm.nih.gov/pubmed/37126445 http://dx.doi.org/10.1016/j.xpro.2023.102267 |