Proteomic Analysis of Huntington’s Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets

Huntington’s disease (HD) is a neurodegenerative disease caused by a CAG repeat expansion in the Huntingtin (HTT) gene. The resulting polyglutamine (polyQ) tract alters the function of the HTT protein. Although HTT is expressed in different tissues, the medium-spiny projection neurons (MSNs) in the...

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Detalles Bibliográficos
Autores principales: Tshilenge, Kizito-Tshitoko, Aguirre, Carlos Galicia, Bons, Joanna, Gerencser, Akos A., Basisty, Nathan, Song, Sicheng, Rose, Jacob, Lopez-Ramirez, Alejandro, Naphade, Swati, Loureiro, Ashley, Battistoni, Elena, Milani, Mateus, Wehrfritz, Cameron, Holtz, Anja, Hetz, Claudio, Mooney, Sean D., Schilling, Birgit, Ellerby, Lisa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165459/
https://www.ncbi.nlm.nih.gov/pubmed/36958627
http://dx.doi.org/10.1016/j.mcpro.2023.100534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165459/
https://www.ncbi.nlm.nih.gov/pubmed/36958627
http://dx.doi.org/10.1016/j.mcpro.2023.100534

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