Cargando…

Panax notoginseng saponins inhibits NLRP3 inflammasome-mediated pyroptosis by downregulating lncRNA-ANRIL in cardiorenal syndrome type 4

OBJECTIVE: Cardiorenal syndrome type 4 (CRS4) is a complication of chronic kidney disease. Panax notoginseng saponins (PNS) have been confirmed to be efficient in cardiovascular diseases. Our study aimed to explore the therapeutic role and mechanism of PNS in CRS4. METHODS: CRS4 model rats and hypox...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Ying, Cao, Luxi, Zou, Wenli, Yu, Rizhen, Shen, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165771/ https://www.ncbi.nlm.nih.gov/pubmed/37158944 http://dx.doi.org/10.1186/s13020-023-00756-2

Ejemplares similares

Saponin accumulation in the seedling root of Panax notoginseng
por: Wang, Dong, et al.
Publicado: (2011)

New dammarane-type triterpenoid saponins from Panax notoginseng saponins
por: Li, Qian, et al.
Publicado: (2020)

Pustular drug eruption due to Panax notoginseng saponins
por: Yin, ZhiQiang, et al.
Publicado: (2014)

Stereoisomers of Saponins in Panax notoginseng (Sanqi): A Review
por: Peng, Ming, et al.
Publicado: (2018)

Effect of the combination of astragaloside IV and Panax notoginseng saponins on pyroptosis and necroptosis in rat models of cerebral ischemia-reperfusion
por: Tang, Biao, et al.
Publicado: (2021)

High-throughput transcriptional profiling of perturbations by Panax ginseng saponins and Panax notoginseng saponins using TCM-seq
por: Cheng, Junyun, et al.
Publicado: (2023)

Pharmacokinetics study of bio-adhesive tablet of Panax notoginseng saponins
por: Feng, Hanzhou, et al.
Publicado: (2011)

Dammarane-type saponins from steamed leaves of Panax Notoginseng
por: Liu, Qing, et al.
Publicado: (2011)

Dammarane-type Triterpene Saponins from the Flowers of Panax notoginseng
por: Wang, Jing-Rong, et al.
Publicado: (2009)

Metabolomes and transcriptomes revealed the saponin distribution in root tissues of Panax quinquefolius and Panax notoginseng
por: Wei, Guangfei, et al.
Publicado: (2020)

Chemical transformation and target preparation of saponins in stems and leaves of Panax notoginseng
por: Wang, Ru-Feng, et al.
Publicado: (2018)

Integrated metabolomic and transcriptomic analyses revealed the distribution of saponins in Panax notoginseng
por: Wei, Guangfei, et al.
Publicado: (2018)

Effects of Panax Notoginseng Saponins on Esterases Responsible for Aspirin Hydrolysis In Vitro
por: Sun, Zongxi, et al.
Publicado: (2018)

Structure and Location Studies on Key Enzymes in Saponins Biosynthesis of Panax notoginseng
por: Xia, Pengguo, et al.
Publicado: (2019)

Pharmacological Effect of Panax notoginseng Saponins on Cerebral Ischemia in Animal Models
por: Dong, Chao, et al.
Publicado: (2022)

Downregulation of lncRNA ANRIL suppresses growth and metastasis in human osteosarcoma cells
por: Guan, Hongya, et al.
Publicado: (2018)

Anaphylactic Rare Saponins Separated from Panax notoginseng Saponin and a Proteomic Approach to Their Anaphylactic Mechanism
por: Hao, Feiran, et al.
Publicado: (2022)

Quantitative Comparison and Metabolite Profiling of Saponins in Different Parts of the Root of Panax notoginseng
por: Wang, Jing-Rong, et al.
Publicado: (2014)

Effect of Panax notoginseng Saponins and Major Anti-Obesity Components on Weight Loss
por: Zhang, Xuelian, et al.
Publicado: (2021)

Panax notoginseng saponins and their applications in nervous system disorders: a narrative review
por: Qu, Jing, et al.
Publicado: (2020)

Mechanism of lncRNA-ANRIL/miR-181b in autophagy of cardiomyocytes in mice with uremia by targeting ATG5
por: Xu, Ying, et al.
Publicado: (2021)

Panax notoginseng saponin attenuates hypoxia/reoxygenation-induced oxidative stress in cortical neurons★
por: Yan, Chen, et al.
Publicado: (2012)

Panax notoginseng Saponins for Treating Coronary Artery Disease: A Functional and Mechanistic Overview
por: Duan, Lian, et al.
Publicado: (2017)

Panax Notoginseng Saponins Prevent Bone Loss by Promoting Angiogenesis in an Osteoporotic Mouse Model
por: Hu, Hao, et al.
Publicado: (2020)

Panax notoginseng saponins alleviate osteoporosis and joint destruction in rabbits with antigen-induced arthritis
por: Wei, Chen Chao, et al.
Publicado: (2021)

A Network Pharmacology Approach for Exploring the Mechanisms of Panax notoginseng Saponins in Ischaemic Stroke
por: Wang, Cong, et al.
Publicado: (2021)

Physicochemical, Digestive, and Sensory Properties of Panax Notoginseng Saponins Encapsulated by Polymerized Whey Protein
por: Zhou, Zengjia, et al.
Publicado: (2021)

Gut-liver axis modulation of Panax notoginseng saponins in nonalcoholic fatty liver disease
por: Xu, Yu, et al.
Publicado: (2021)

Panax notoginseng Saponin Protects Against Diabetic Cardiomyopathy Through Lipid Metabolism Modulation
por: Zhang, Chenyang, et al.
Publicado: (2022)

Suitable soil moisture contents for water use efficiency and saponins accumulation in Panax notoginseng
por: Zheng, Yu-jie, et al.
Publicado: (2021)

High nitrogen inhibits biomass and saponins accumulation in a medicinal plant Panax notoginseng
por: Cun, Zhu, et al.
Publicado: (2023)

Therapeutic effects of Panax notoginseng saponins in rheumatoid arthritis: network pharmacology and experimental validation
por: Ma, Xinnan, et al.
Publicado: (2023)

LncRNA ANRIL mediates endothelial dysfunction through BDNF downregulation in chronic kidney disease
por: Su, Hong, et al.
Publicado: (2022)

Protective Effects of Panax Notoginseng Saponins on Cardiovascular Diseases: A Comprehensive Overview of Experimental Studies
por: Yang, Xiaochen, et al.
Publicado: (2014)

Panax notoginseng saponins improve recovery after spinal cord transection by upregulating neurotrophic factors
por: Wang, Bo, et al.
Publicado: (2015)

Inhibitory Influence of Panax notoginseng Saponins on Aspirin Hydrolysis in Human Intestinal Caco-2 Cells
por: Sun, Zongxi, et al.
Publicado: (2018)

Integrated Chemical and Transcriptomic Analysis Reveals the Distribution of Protopanaxadiol- and Protopanaxatriol-Type Saponins in Panax notoginseng
por: Wei, Guangfei, et al.
Publicado: (2018)

Intervention Effects of Atorvastatin Combined with Panax notoginseng Saponins on Rats with Atherosclerosis Complicated with Hepatic Injury
por: Jiang, Qing-Fang, et al.
Publicado: (2017)

Exploring the Mechanism of Panax notoginseng Saponins against Alzheimer's Disease by Network Pharmacology and Experimental Validation
por: Jiang, Yixuan, et al.
Publicado: (2021)

Analysis of the Renal Protection and Antioxidative Stress Effects of Panax notoginseng Saponins in Diabetic Nephropathy Mice
por: Mi, Wei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fj5ndrm9jb8i3cnfp1nfkacu8b