Identification of potential resistance mechanisms and therapeutic targets for the relapse of BCMA CAR-T therapy in relapsed/refractory multiple myeloma through single-cell sequencing

BACKGROUND: BCMA CAR-T is highly effective for relapsed/refractory multiple myeloma(R/R-MM) and significantly improves the survival of patients. However, the short remission time and high relapse rate of MM patients treated with BCMA CAR-T remain bottlenecks that limit long-term survival. The immune...

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Detalles Bibliográficos
Autores principales: Li, Wei, Zhang, Binglei, Cao, Weijie, Zhang, Wenli, Li, Tiandong, Liu, Lina, Xu, LinPing, Gao, Fengcai, Wang, Yanmei, Wang, Fang, Xing, Haizhou, Jiang, Zhongxing, Shi, Jianxiang, Bian, Zhilei, Song, Yongping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165782/
https://www.ncbi.nlm.nih.gov/pubmed/37158921
http://dx.doi.org/10.1186/s40164-023-00402-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165782/
https://www.ncbi.nlm.nih.gov/pubmed/37158921
http://dx.doi.org/10.1186/s40164-023-00402-5

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