Selective inhibition of somatostatin-positive dentate hilar interneurons induces age-related cellular changes and cognitive dysfunction

The cellular basis of age-related impairments of hippocampal function is not fully understood. In order to evaluate the role of somatostatin-positive (Sst(+)) interneurons in the dentate gyrus (DG) hilus in this process, we chemogenetically inhibited Sst(+) interneurons in the DG hilus. Chronic chem...

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Detalles Bibliográficos
Autores principales: Lyu, Jinrui, Nagarajan, Rajasekar, Kambali, Maltesh, Wang, Muxiao, Rudolph, Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Biological, Health, and Medical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165806/
https://www.ncbi.nlm.nih.gov/pubmed/37168673
http://dx.doi.org/10.1093/pnasnexus/pgad134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165806/
https://www.ncbi.nlm.nih.gov/pubmed/37168673
http://dx.doi.org/10.1093/pnasnexus/pgad134

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