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Model selection and robust inference of mutational signatures using Negative Binomial non-negative matrix factorization
BACKGROUND: The spectrum of mutations in a collection of cancer genomes can be described by a mixture of a few mutational signatures. The mutational signatures can be found using non-negative matrix factorization (NMF). To extract the mutational signatures we have to assume a distribution for the ob...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165836/ https://www.ncbi.nlm.nih.gov/pubmed/37158829 http://dx.doi.org/10.1186/s12859-023-05304-1 |