Physicochemical and Biopharmaceutical Controllability of New Self-Assembled Fatty Acid Conjugated Leuprolide for the Enhanced Anticancer Activity

BACKGROUND: Leuprolide (LEU), a synthetic nonapeptide analog of naturally occurring gonadotropin-releasing hormone (GnRH), could exert a direct inhibitory activity on the proliferation of prostate cancer cells. However, the short half-life in blood and the biopharmaceutical problem of LEU limit this...

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Detalles Bibliográficos
Autores principales: Ngo, Hai V, Bak, Hye-Eun, Nguyen, Hy D, Lee, Kye Wan, Park, Chulhun, Lee, Beom-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166105/
https://www.ncbi.nlm.nih.gov/pubmed/37168738
http://dx.doi.org/10.2147/IJN.S401048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166105/
https://www.ncbi.nlm.nih.gov/pubmed/37168738
http://dx.doi.org/10.2147/IJN.S401048

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