A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration

Emerging evidence suggests that intron-detaining transcripts (IDTs) are a nucleus-detained and polyadenylated mRNA pool for cell to quickly and effectively respond to environmental stimuli and stress. However, the underlying mechanisms of detained intron (DI) splicing are still largely unknown. Here...

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Detalles Bibliográficos
Autores principales: Meng, Dawei, Zheng, Qian, Zhang, Xue, Piao, Xuejiao, Luo, Li, Jia, Yichang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166177/
https://www.ncbi.nlm.nih.gov/pubmed/37027487
http://dx.doi.org/10.1093/procel/pwac008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166177/
https://www.ncbi.nlm.nih.gov/pubmed/37027487
http://dx.doi.org/10.1093/procel/pwac008

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