Network analysis of toxin production in Clostridioides difficile identifies key metabolic dependencies

Clostridioides difficile pathogenesis is mediated through its two toxin proteins, TcdA and TcdB, which induce intestinal epithelial cell death and inflammation. It is possible to alter C. difficile toxin production by changing various metabolite concentrations within the extracellular environment. H...

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Detalles Bibliográficos
Autores principales: Powers, Deborah A., Jenior, Matthew L., Kolling, Glynis L., Papin, Jason A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166488/
https://www.ncbi.nlm.nih.gov/pubmed/37099624
http://dx.doi.org/10.1371/journal.pcbi.1011076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166488/
https://www.ncbi.nlm.nih.gov/pubmed/37099624
http://dx.doi.org/10.1371/journal.pcbi.1011076

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