Myeloid expression of the anti-apoptotic protein Mcl1 is required in anti-myeloperoxidase vasculitis but myeloperoxidase inhibition is not protective

Antibodies to neutrophil and monocyte myeloperoxidase and proteinase 3 are a feature of anti-neutrophil cytoplasmic antibody vasculitis, a disease with significant morbidity for which new treatments are needed. Mice with a myeloid-specific deletion of the anti-apoptotic protein Mcl1 have reduced num...

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Detalles Bibliográficos
Autores principales: Florez-Barros, Fernanda, Bearder, Siobhan, Kull, Bengt, Freeman, Adrian, Mócsai, Attila, Robson, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Basic Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166712/
https://www.ncbi.nlm.nih.gov/pubmed/36154801
http://dx.doi.org/10.1016/j.kint.2022.08.028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166712/
https://www.ncbi.nlm.nih.gov/pubmed/36154801
http://dx.doi.org/10.1016/j.kint.2022.08.028

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