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Hypoxia‐induced oxidative stress promotes therapy resistance via upregulation of heme oxygenase‐1 in multiple myeloma

BACKGROUND: Multiple myeloma (MM) is a hematopoietic malignancy for which proteasome inhibitors have become available in recent years. However, many patients develop resistance to these drugs during treatment. Therefore, it is important to elucidate the mechanisms underlying resistance acquisition b...

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Detalles Bibliográficos
Autores principales: Abe, Ko, Ikeda, Sho, Nara, Miho, Kitadate, Akihiro, Tagawa, Hiroyuki, Takahashi, Naoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166934/
https://www.ncbi.nlm.nih.gov/pubmed/36775962
http://dx.doi.org/10.1002/cam4.5679