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Anti‐CLL1‐based CAR T‐cells with 4‐1‐BB or CD28/CD27 stimulatory domains in treating childhood refractory/relapsed acute myeloid leukemia

BACKGROUND: Though the efficacy of anti C‐type lectin‐like molecule‐1 (CLL1) CAR T‐cells in refractory/relapsed acute myeloid leukemia (R/R‐AML) have been occasionally reported, the influence of co‐stimulatory domain CAR T‐cells is not investigated so far. METHOD: Seven R/R‐AML children treated with...

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Detalles Bibliográficos
Autores principales: Pei, Kunlin, Xu, Haoyu, Wang, Pengfei, Gan, Wening, Hu, Zhengbin, Su, Xiaoling, Zhang, Hui, He, Yingyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166968/
https://www.ncbi.nlm.nih.gov/pubmed/37031462
http://dx.doi.org/10.1002/cam4.5916