Virtual screening of ultra-large chemical libraries identifies cell-permeable small-molecule inhibitors of a “non-druggable” target, STAT3 N-terminal domain

STAT3 N-terminal domain is a promising molecular target for cancer treatment and modulation of immune responses. However, STAT3 is localized in the cytoplasm, mitochondria, and nuclei, and thus, is inaccessible to therapeutic antibodies. Its N-terminal domain lacks deep pockets on the surface and re...

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Detalles Bibliográficos
Autores principales: Bonilla, Pedro Andrade, Hoop, Cody L., Stefanisko, Karen, Tarasov, Sergey G., Sinha, Sourav, Nicklaus, Marc C., Tarasova, Nadya I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167007/
https://www.ncbi.nlm.nih.gov/pubmed/37182134
http://dx.doi.org/10.3389/fonc.2023.1144153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167007/
https://www.ncbi.nlm.nih.gov/pubmed/37182134
http://dx.doi.org/10.3389/fonc.2023.1144153

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