Short hydrophobic loop motifs in BRICHOS domains determine chaperone activity against amorphous protein aggregation but not against amyloid formation

ATP-independent molecular chaperones are important for maintaining cellular fitness but the molecular determinants for preventing aggregation of partly unfolded protein substrates remain unclear, particularly regarding assembly state and basis for substrate recognition. The BRICHOS domain can perfor...

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Detalles Bibliográficos
Autores principales: Chen, Gefei, Leppert, Axel, Poska, Helen, Nilsson, Harriet E., Alvira, Carlos Piedrafita, Zhong, Xueying, Koeck, Philip, Jegerschöld, Caroline, Abelein, Axel, Hebert, Hans, Johansson, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167226/
https://www.ncbi.nlm.nih.gov/pubmed/37156997
http://dx.doi.org/10.1038/s42003-023-04883-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167226/
https://www.ncbi.nlm.nih.gov/pubmed/37156997
http://dx.doi.org/10.1038/s42003-023-04883-2

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