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Neutralization of excessive levels of active TGF-β1 reduces MSC recruitment and differentiation to mitigate peritendinous adhesion

Peritendinous adhesion formation (PAF) can substantially limit the range of motion of digits. However, the origin of myofibroblasts in PAF tissues is still unclear. In this study, we found that the concentration of active TGF-β1 and the numbers of macrophages, mesenchymal stromal cells (MSCs), and m...

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Detalles Bibliográficos
Autores principales: Li, YuSheng, Wang, Xiao, Hu, Bo, Sun, Qi, Wan, Mei, Carr, Andrew, Liu, Shen, Cao, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167238/
https://www.ncbi.nlm.nih.gov/pubmed/37156778
http://dx.doi.org/10.1038/s41413-023-00252-1