Development and characterization of agonistic antibodies targeting the Ig-like 1 domain of MuSK

Muscle-specific kinase (MuSK) is crucial for acetylcholine receptor (AChR) clustering and thereby neuromuscular junction (NMJ) function. NMJ dysfunction is a hallmark of several neuromuscular diseases, including MuSK myasthenia gravis. Aiming to restore NMJ function, we generated several agonist mon...

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Detalles Bibliográficos
Autores principales: Lim, Jamie L., Augustinus, Roy, Plomp, Jaap J., Roya-Kouchaki, Kasra, Vergoossen, Dana L. E., Fillié-Grijpma, Yvonne, Struijk, Josephine, Thomas, Rachel, Salvatori, Daniela, Steyaert, Christophe, Blanchetot, Christophe, Vanhauwaert, Roeland, Silence, Karen, van der Maarel, Silvère M., Verschuuren, Jan J., Huijbers, Maartje G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167245/
https://www.ncbi.nlm.nih.gov/pubmed/37156800
http://dx.doi.org/10.1038/s41598-023-32641-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167245/
https://www.ncbi.nlm.nih.gov/pubmed/37156800
http://dx.doi.org/10.1038/s41598-023-32641-1

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