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Fluorescence resonance energy transfer (FRET) spatiotemporal mapping of atypical P38 reveals an endosomal and cytosolic spatial bias

Mitogen-activated protein kinase (MAPK) p38 is a central regulator of intracellular signaling, driving physiological and pathological pathways. With over 150 downstream targets, it is predicted that spatial positioning and the availability of cofactors and substrates determines kinase signaling spec...

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Detalles Bibliográficos
Autores principales: Burton, Jeremy C., Okalova, Jennifer, Grimsey, Neil J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167256/
https://www.ncbi.nlm.nih.gov/pubmed/37156828
http://dx.doi.org/10.1038/s41598-023-33953-y