Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction

Many proteins involved in eukaryotic phosphate homeostasis are regulated by SPX domains. In yeast, the vacuolar transporter chaperone (VTC) complex contains two such domains, but mechanistic details of its regulation are not well understood. Here, we show at the atomic level how inositol pyrophospha...

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Detalles Bibliográficos
Autores principales: Pipercevic, Joka, Kohl, Bastian, Gerasimaite, Ruta, Comte-Miserez, Véronique, Hostachy, Sarah, Müntener, Thomas, Agustoni, Elia, Jessen, Henning Jacob, Fiedler, Dorothea, Mayer, Andreas, Hiller, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167327/
https://www.ncbi.nlm.nih.gov/pubmed/37156835
http://dx.doi.org/10.1038/s41467-023-38315-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167327/
https://www.ncbi.nlm.nih.gov/pubmed/37156835
http://dx.doi.org/10.1038/s41467-023-38315-w

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