Optimized spirooxindole-pyrazole hybrids targeting the p53-MDM2 interplay induce apoptosis and synergize with doxorubicin in A549 cells

Recently, cancer research protocols have introduced clinical-stage spirooxindole-based MDM2 inhibitors. However, several studies reported tumor resistance to the treatment. This directed efforts to invest in designing various combinatorial libraries of spirooxindoles. Herein, we introduce new series...

Descripción completa

Detalles Bibliográficos
Autores principales: Islam, Mohammad Shahidul, Al-Majid, Abdullah Mohammed, Sholkamy, Essam Nageh, Barakat, Assem, Viale, Maurizio, Menichini, Paola, Speciale, Andrea, Loiacono, Fabrizio, Azam, Mohammad, Verma, Ved Prakash, Yousuf, Sammer, Teleb, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167355/
https://www.ncbi.nlm.nih.gov/pubmed/37156796
http://dx.doi.org/10.1038/s41598-023-31209-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167355/
https://www.ncbi.nlm.nih.gov/pubmed/37156796
http://dx.doi.org/10.1038/s41598-023-31209-3

Ejemplares similares