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Optimized spirooxindole-pyrazole hybrids targeting the p53-MDM2 interplay induce apoptosis and synergize with doxorubicin in A549 cells

Recently, cancer research protocols have introduced clinical-stage spirooxindole-based MDM2 inhibitors. However, several studies reported tumor resistance to the treatment. This directed efforts to invest in designing various combinatorial libraries of spirooxindoles. Herein, we introduce new series...

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Detalles Bibliográficos
Autores principales:	Islam, Mohammad Shahidul, Al-Majid, Abdullah Mohammed, Sholkamy, Essam Nageh, Barakat, Assem, Viale, Maurizio, Menichini, Paola, Speciale, Andrea, Loiacono, Fabrizio, Azam, Mohammad, Verma, Ved Prakash, Yousuf, Sammer, Teleb, Mohamed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167355/ https://www.ncbi.nlm.nih.gov/pubmed/37156796 http://dx.doi.org/10.1038/s41598-023-31209-3

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