Hydrogen-Bonding Ability of Noyori–Ikariya Catalysts Enables Stereoselective Access to CF(3)-Substituted syn-1,2-Diols via Dynamic Kinetic Resolution

[Image: see text] Stereopure CF(3)-substituted syn-1,2-diols were prepared via the reductive dynamic kinetic resolution of the corresponding racemic α-hydroxyketones in HCO(2)H/Et(3)N. (Het)aryl, benzyl, vinyl, and alkyl ketones are tolerated, delivering products with ≥95% ee and ≥87:13 syn/anti. Th...

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Detalles Bibliográficos
Autores principales: Sterle, Maša, Huš, Matej, Lozinšek, Matic, Zega, Anamarija, Cotman, Andrej Emanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167654/
https://www.ncbi.nlm.nih.gov/pubmed/37180962
http://dx.doi.org/10.1021/acscatal.3c00980

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167654/
https://www.ncbi.nlm.nih.gov/pubmed/37180962
http://dx.doi.org/10.1021/acscatal.3c00980

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