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FLEXR: automated multi-conformer model building using electron-density map sampling

Protein conformational dynamics that may inform biology often lie dormant in high-resolution electron-density maps. While an estimated ∼18% of side chains in high-resolution models contain alternative conformations, these are underrepresented in current PDB models due to difficulties in manually det...

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Detalles Bibliográficos
Autores principales: Stachowski, Timothy R., Fischer, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167668/
https://www.ncbi.nlm.nih.gov/pubmed/37071395
http://dx.doi.org/10.1107/S2059798323002498