Structural insight into an anti-BRIL Fab as a G-protein-coupled receptor crystallization chaperone

Structure determination of G-protein-coupled receptors (GPCRs) is key for the successful development of efficient drugs targeting GPCRs. BRIL is a thermostabilized apocytochrome b (562) (with M7W/H102I/R106L mutations) from Escherichia coli and is often used as a GPCR fusion protein for expression a...

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Detalles Bibliográficos
Autores principales: Miyagi, Hikaru, Suzuki, Michihiko, Yasunaga, Mai, Asada, Hidetsugu, Iwata, So, Saito, Jun-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2023
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167669/
https://www.ncbi.nlm.nih.gov/pubmed/37098908
http://dx.doi.org/10.1107/S205979832300311X

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167669/
https://www.ncbi.nlm.nih.gov/pubmed/37098908
http://dx.doi.org/10.1107/S205979832300311X

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