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Continuous-Flow Synthesis of Δ(9)-Tetrahydrocannabinol and Δ(8)-Tetrahydrocannabinol from Cannabidiol

[Image: see text] A challenging step in the preparation of tetrahydrocannabinol analogs is an acid-catalyzed intramolecular cyclization of the cannabidiol precursor. This step typically affords a mixture of products, which requires extensive purification to obtain any pure products. We report the de...

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Detalles Bibliográficos
Autores principales: Bassetti, Benedetta, Hone, Christopher A., Kappe, C. Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167683/
https://www.ncbi.nlm.nih.gov/pubmed/37014222
http://dx.doi.org/10.1021/acs.joc.3c00300