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Tandem addition of nucleophilic and electrophilic reagents to vinyl phosphinates: the stereoselective formation of organophosphorus compounds with congested tertiary carbons

Carbon anions formed via the addition of Grignard reagents to S(P)-vinyl phosphinates were modified with electrophilic reagents to afford organophosphorus compounds with diverse carbon skeletons. The electrophiles included acids, aldehydes, epoxy groups, chalcogens and alkyl halides. When alkyl hali...

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Autores principales: Lin, Zhu, Zhai, De-Hua, Sun, Yong-Ming, Zheng, Hong-Xing, Li, Qiang, Wang, Yan-Lan, Wen, Jing-Hong, Zhao, Chang-Qiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167796/
https://www.ncbi.nlm.nih.gov/pubmed/37179997
http://dx.doi.org/10.1039/d3ra02409a
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author Lin, Zhu
Zhai, De-Hua
Sun, Yong-Ming
Zheng, Hong-Xing
Li, Qiang
Wang, Yan-Lan
Wen, Jing-Hong
Zhao, Chang-Qiu
author_facet Lin, Zhu
Zhai, De-Hua
Sun, Yong-Ming
Zheng, Hong-Xing
Li, Qiang
Wang, Yan-Lan
Wen, Jing-Hong
Zhao, Chang-Qiu
author_sort Lin, Zhu
collection PubMed
description Carbon anions formed via the addition of Grignard reagents to S(P)-vinyl phosphinates were modified with electrophilic reagents to afford organophosphorus compounds with diverse carbon skeletons. The electrophiles included acids, aldehydes, epoxy groups, chalcogens and alkyl halides. When alkyl halides were used, bis-alkylated products were afforded. Substitution reactions or polymerization occurred when the reaction was applied to vinyl phosphine oxides.
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spelling pubmed-101677962023-05-10 Tandem addition of nucleophilic and electrophilic reagents to vinyl phosphinates: the stereoselective formation of organophosphorus compounds with congested tertiary carbons Lin, Zhu Zhai, De-Hua Sun, Yong-Ming Zheng, Hong-Xing Li, Qiang Wang, Yan-Lan Wen, Jing-Hong Zhao, Chang-Qiu RSC Adv Chemistry Carbon anions formed via the addition of Grignard reagents to S(P)-vinyl phosphinates were modified with electrophilic reagents to afford organophosphorus compounds with diverse carbon skeletons. The electrophiles included acids, aldehydes, epoxy groups, chalcogens and alkyl halides. When alkyl halides were used, bis-alkylated products were afforded. Substitution reactions or polymerization occurred when the reaction was applied to vinyl phosphine oxides. The Royal Society of Chemistry 2023-05-09 /pmc/articles/PMC10167796/ /pubmed/37179997 http://dx.doi.org/10.1039/d3ra02409a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Lin, Zhu
Zhai, De-Hua
Sun, Yong-Ming
Zheng, Hong-Xing
Li, Qiang
Wang, Yan-Lan
Wen, Jing-Hong
Zhao, Chang-Qiu
Tandem addition of nucleophilic and electrophilic reagents to vinyl phosphinates: the stereoselective formation of organophosphorus compounds with congested tertiary carbons
title Tandem addition of nucleophilic and electrophilic reagents to vinyl phosphinates: the stereoselective formation of organophosphorus compounds with congested tertiary carbons
title_full Tandem addition of nucleophilic and electrophilic reagents to vinyl phosphinates: the stereoselective formation of organophosphorus compounds with congested tertiary carbons
title_fullStr Tandem addition of nucleophilic and electrophilic reagents to vinyl phosphinates: the stereoselective formation of organophosphorus compounds with congested tertiary carbons
title_full_unstemmed Tandem addition of nucleophilic and electrophilic reagents to vinyl phosphinates: the stereoselective formation of organophosphorus compounds with congested tertiary carbons
title_short Tandem addition of nucleophilic and electrophilic reagents to vinyl phosphinates: the stereoselective formation of organophosphorus compounds with congested tertiary carbons
title_sort tandem addition of nucleophilic and electrophilic reagents to vinyl phosphinates: the stereoselective formation of organophosphorus compounds with congested tertiary carbons
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167796/
https://www.ncbi.nlm.nih.gov/pubmed/37179997
http://dx.doi.org/10.1039/d3ra02409a
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