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Tandem addition of nucleophilic and electrophilic reagents to vinyl phosphinates: the stereoselective formation of organophosphorus compounds with congested tertiary carbons
Carbon anions formed via the addition of Grignard reagents to S(P)-vinyl phosphinates were modified with electrophilic reagents to afford organophosphorus compounds with diverse carbon skeletons. The electrophiles included acids, aldehydes, epoxy groups, chalcogens and alkyl halides. When alkyl hali...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167796/ https://www.ncbi.nlm.nih.gov/pubmed/37179997 http://dx.doi.org/10.1039/d3ra02409a |
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author | Lin, Zhu Zhai, De-Hua Sun, Yong-Ming Zheng, Hong-Xing Li, Qiang Wang, Yan-Lan Wen, Jing-Hong Zhao, Chang-Qiu |
author_facet | Lin, Zhu Zhai, De-Hua Sun, Yong-Ming Zheng, Hong-Xing Li, Qiang Wang, Yan-Lan Wen, Jing-Hong Zhao, Chang-Qiu |
author_sort | Lin, Zhu |
collection | PubMed |
description | Carbon anions formed via the addition of Grignard reagents to S(P)-vinyl phosphinates were modified with electrophilic reagents to afford organophosphorus compounds with diverse carbon skeletons. The electrophiles included acids, aldehydes, epoxy groups, chalcogens and alkyl halides. When alkyl halides were used, bis-alkylated products were afforded. Substitution reactions or polymerization occurred when the reaction was applied to vinyl phosphine oxides. |
format | Online Article Text |
id | pubmed-10167796 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-101677962023-05-10 Tandem addition of nucleophilic and electrophilic reagents to vinyl phosphinates: the stereoselective formation of organophosphorus compounds with congested tertiary carbons Lin, Zhu Zhai, De-Hua Sun, Yong-Ming Zheng, Hong-Xing Li, Qiang Wang, Yan-Lan Wen, Jing-Hong Zhao, Chang-Qiu RSC Adv Chemistry Carbon anions formed via the addition of Grignard reagents to S(P)-vinyl phosphinates were modified with electrophilic reagents to afford organophosphorus compounds with diverse carbon skeletons. The electrophiles included acids, aldehydes, epoxy groups, chalcogens and alkyl halides. When alkyl halides were used, bis-alkylated products were afforded. Substitution reactions or polymerization occurred when the reaction was applied to vinyl phosphine oxides. The Royal Society of Chemistry 2023-05-09 /pmc/articles/PMC10167796/ /pubmed/37179997 http://dx.doi.org/10.1039/d3ra02409a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Lin, Zhu Zhai, De-Hua Sun, Yong-Ming Zheng, Hong-Xing Li, Qiang Wang, Yan-Lan Wen, Jing-Hong Zhao, Chang-Qiu Tandem addition of nucleophilic and electrophilic reagents to vinyl phosphinates: the stereoselective formation of organophosphorus compounds with congested tertiary carbons |
title | Tandem addition of nucleophilic and electrophilic reagents to vinyl phosphinates: the stereoselective formation of organophosphorus compounds with congested tertiary carbons |
title_full | Tandem addition of nucleophilic and electrophilic reagents to vinyl phosphinates: the stereoselective formation of organophosphorus compounds with congested tertiary carbons |
title_fullStr | Tandem addition of nucleophilic and electrophilic reagents to vinyl phosphinates: the stereoselective formation of organophosphorus compounds with congested tertiary carbons |
title_full_unstemmed | Tandem addition of nucleophilic and electrophilic reagents to vinyl phosphinates: the stereoselective formation of organophosphorus compounds with congested tertiary carbons |
title_short | Tandem addition of nucleophilic and electrophilic reagents to vinyl phosphinates: the stereoselective formation of organophosphorus compounds with congested tertiary carbons |
title_sort | tandem addition of nucleophilic and electrophilic reagents to vinyl phosphinates: the stereoselective formation of organophosphorus compounds with congested tertiary carbons |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167796/ https://www.ncbi.nlm.nih.gov/pubmed/37179997 http://dx.doi.org/10.1039/d3ra02409a |
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