Genetic Polymorphisms in SLCO2B1 and ABCC1 Conjointly Modulate Atorvastatin Intracellular Accumulation in HEK293 Recombinant Cell Lines

Although atorvastatin (ATV) is well-tolerated, patients may report muscle complaints. These are difficult to predict owing to high interindividual variability. Such side effects are linked to intramuscular accumulation of ATV. This study aimed to investigate the relative role of transporters express...

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Detalles Bibliográficos
Autores principales: Hoste, Emilia, Paquot, Adrien, Panin, Nadtha, Horion, Shaleena, El Hamdaoui, Halima, Muccioli, Giulio G., Haufroid, Vincent, Elens, Laure
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Therapeutic Drug Monitoring 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168106/
https://www.ncbi.nlm.nih.gov/pubmed/36253893
http://dx.doi.org/10.1097/FTD.0000000000001043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168106/
https://www.ncbi.nlm.nih.gov/pubmed/36253893
http://dx.doi.org/10.1097/FTD.0000000000001043

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