Cargando…

Alpha Synuclein Modulates Mitochondrial Ca(2+) Uptake from ER During Cell Stimulation and Under Stress Conditions

Mostrar otras versiones (1)

Alpha synuclein (a-syn) is an intrinsically disordered protein prevalent in neurons, and aggregated forms are associated with synucleinopathies including Parkinson’ disease (PD). Despite the biomedical importance and extensive studies, the physiological role of a-syn and its participation in etiolog...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ramezani, Meraj, Wagenknecht-Wiesner, Alice, Wang, Tong, Holowka, David A., Eliezer, David, Baird, Barbara A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168219/ https://www.ncbi.nlm.nih.gov/pubmed/37163091 http://dx.doi.org/10.1101/2023.04.23.537965

Ejemplares similares

Alpha synuclein modulates mitochondrial Ca(2+) uptake from ER during cell stimulation and under stress conditions
por: Ramezani, Meraj, et al.
Publicado: (2023)

Regulation of exocytosis and mitochondrial relocalization by Alpha-synuclein in a mammalian cell model
por: Ramezani, Meraj, et al.
Publicado: (2019)

Sequestration of phosphoinositides by mutated MARCKS effector domain inhibits stimulated Ca(2+) mobilization and degranulation in mast cells
por: Gadi, Deepti, et al.
Publicado: (2011)

The Role of Membrane Affinity and Binding Modes in Alpha-Synuclein Regulation of Vesicle Release and Trafficking
por: Das, Tapojyoti, et al.
Publicado: (2022)

Alpha-Synuclein Function and Dysfunction on Cellular Membranes
por: Snead, David, et al.
Publicado: (2014)

Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts
por: Braidy, Nady, et al.
Publicado: (2013)

Activation of Cdc42 is necessary for sustained oscillations of Ca(2+) and PIP(2) stimulated by antigen in RBL mast cells
por: Wilkes, Marcus M., et al.
Publicado: (2014)

The relationship of alpha-synuclein to mitochondrial dynamics and quality control
por: Thorne, Naomi J., et al.
Publicado: (2022)

Molecular and functional interactions of alpha-synuclein with Rab3a
por: Lv, Guohua, et al.
Publicado: (2022)

OPA1 Modulates Mitochondrial Ca(2+) Uptake Through ER-Mitochondria Coupling
por: Cartes-Saavedra, Benjamín, et al.
Publicado: (2022)

α-Synuclein binds to the ER–mitochondria tethering protein VAPB to disrupt Ca(2+) homeostasis and mitochondrial ATP production
por: Paillusson, Sébastien, et al.
Publicado: (2017)

Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes
por: Gustafsson, Gabriel, et al.
Publicado: (2017)

Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD
por: Esteves, A. R., et al.
Publicado: (2011)

Dopamine, Alpha-Synuclein, and Mitochondrial Dysfunctions in Parkinsonian Eyes
por: Indrieri, Alessia, et al.
Publicado: (2020)

Depolarization-induced Calcium Responses in Sympathetic Neurons: Relative Contributions from Ca(2+) Entry, Extrusion, ER/Mitochondrial Ca(2+) Uptake and Release, and Ca(2+) Buffering
por: Patterson, Michael, et al.
Publicado: (2007)

The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome
por: Park, Hyo-Jin, et al.
Publicado: (2017)

Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells
por: Kim, Changyoun, et al.
Publicado: (2021)

Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein
por: Dening, Yanina, et al.
Publicado: (2022)

Alpha-Synuclein Preserves Mitochondrial Fusion and Function in Neuronal Cells
por: Faustini, Gaia, et al.
Publicado: (2019)

KLK6 proteolysis is implicated in the turnover and uptake of extracellular alpha-synuclein species
por: Pampalakis, Georgios, et al.
Publicado: (2016)

Alpha-synuclein stimulation of astrocytes: Potential role for neuroinflammation and neuroprotection
por: Lee, He-Jin, et al.
Publicado: (2010)

Impaired Baroreflex Function in Mice Overexpressing Alpha-Synuclein
por: Fleming, Sheila M., et al.
Publicado: (2013)

SUMOylation of Alpha-Synuclein Influences on Alpha-Synuclein Aggregation Induced by Methamphetamine
por: Zhu, Lin-nan, et al.
Publicado: (2018)

Capture at the ER-mitochondrial contacts licenses IP(3) receptors to stimulate local Ca(2+) transfer and oxidative metabolism
por: Katona, Máté, et al.
Publicado: (2022)

Differential Regulation of ER Ca(2+) Uptake and Release Rates Accounts for Multiple Modes of Ca(2+)-induced Ca(2+) Release
por: Albrecht, Meredith A., et al.
Publicado: (2002)

Alpha-Synuclein Is a Cellular Ferrireductase
por: Davies, Paul, et al.
Publicado: (2011)

Roles for Ca(2+) Mobilization and Its Regulation in Mast Cell Functions
por: Holowka, David, et al.
Publicado: (2012)

Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease: The Emerging Role of VDAC
por: Risiglione, Pierpaolo, et al.
Publicado: (2021)

Direct current stimulation enhances neuronal alpha-synuclein degradation in vitro
por: Sala, Gessica, et al.
Publicado: (2021)

The Temporal Expression Pattern of Alpha-Synuclein Modulates Olfactory Neurogenesis in Transgenic Mice
por: Schreglmann, Sebastian R., et al.
Publicado: (2015)

Differential Effects of UCHL1 Modulation on Alpha-Synuclein in PD-Like Models of Alpha-Synucleinopathy
por: Cartier, Anna E., et al.
Publicado: (2012)

Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity
por: Hu, Di, et al.
Publicado: (2019)

Alpha-Synuclein FRET Biosensors Reveal Early Alpha-Synuclein Aggregation in the Endoplasmic Reticulum
por: Miraglia, Fabiana, et al.
Publicado: (2020)

Correction: Alpha-Synuclein Is a Cellular Ferrireductase
por: Davies, Paul, et al.
Publicado: (2011)

INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division
por: Chakrabarti, Rajarshi, et al.
Publicado: (2018)

Calcium: Alpha-Synuclein Interactions in Alpha-Synucleinopathies
por: Rcom-H'cheo-Gauthier, Alexandre N., et al.
Publicado: (2016)

Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies
por: Okita, Yuho, et al.
Publicado: (2017)

Cardiac Alpha-Synuclein Is Present in Alpha-Synucleinopathies
por: Javanshiri, Keivan, et al.
Publicado: (2022)

Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts
por: Ardah, Mustafa T., et al.
Publicado: (2020)

Ryanodine receptor-mediated Ca(2+) release underlies iron-induced mitochondrial fission and stimulates mitochondrial Ca(2+) uptake in primary hippocampal neurons
por: SanMartín, Carol D., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_rkm0ju7f121bvllpee5oim7rd2