Transcriptional immune suppression and upregulation of double stranded DNA damage and repair repertoires in ecDNA-containing tumors

Extrachromosomal DNA is a common cause of oncogene amplification in cancer. The non-chromosomal inheritance of ecDNA enables tumors to rapidly evolve, contributing to treatment resistance and poor outcome for patients. The transcriptional context in which ecDNAs arise and progress, including chromos...

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Detalles Bibliográficos
Autores principales: Lin, Miin S., Jo, Se-Young, Luebeck, Jens, Chang, Howard Y., Wu, Sihan, Mischel, Paul S., Bafna, Vineet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168239/
https://www.ncbi.nlm.nih.gov/pubmed/37162993
http://dx.doi.org/10.1101/2023.04.24.537925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168239/
https://www.ncbi.nlm.nih.gov/pubmed/37162993
http://dx.doi.org/10.1101/2023.04.24.537925

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