Tumor cell heterogeneity drives spatial organization of the intratumoral immune response in squamous cell skin carcinoma

Intratumoral heterogeneity (ITH)—defined as genetic and cellular diversity within a tumor—is linked to failure of immunotherapy and an inferior anti-tumor immune response. The underlying mechanism of this association is unknown. To address this question, we modeled heterogeneous tumors comprised of...

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Detalles Bibliográficos
Autores principales: Tanaka, Miho, Lum, Lotus, Hu, Kenneth, Ledezma-Soto, Cecilia, Samad, Bushra, Superville, Daphne, Ng, Kenneth, Adams, Zoe, Kersten, Kelly, Fong, Lawrence, Combes, Alexis J., Krummel, Matthew, Reeves, Melissa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168251/
https://www.ncbi.nlm.nih.gov/pubmed/37162860
http://dx.doi.org/10.1101/2023.04.25.538140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168251/
https://www.ncbi.nlm.nih.gov/pubmed/37162860
http://dx.doi.org/10.1101/2023.04.25.538140

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