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Tumor cell heterogeneity drives spatial organization of the intratumoral immune response in squamous cell skin carcinoma
Intratumoral heterogeneity (ITH)—defined as genetic and cellular diversity within a tumor—is linked to failure of immunotherapy and an inferior anti-tumor immune response. The underlying mechanism of this association is unknown. To address this question, we modeled heterogeneous tumors comprised of...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168251/ https://www.ncbi.nlm.nih.gov/pubmed/37162860 http://dx.doi.org/10.1101/2023.04.25.538140 |