The conformational landscape of a serpin N-terminal subdomain facilitates folding and in-cell quality control

Many multi-domain proteins including the serpin family of serine protease inhibitors contain non-sequential domains composed of regions that are far apart in sequence. Because proteins are translated vectorially from N- to C-terminus, such domains pose a particular challenge: how to balance the conf...

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Detalles Bibliográficos
Autores principales: Kaur, Upneet, Kihn, Kyle C., Ke, Haiping, Kuo, Weiwei, Gierasch, Lila M., Hebert, Daniel N., Wintrode, Patrick L., Deredge, Daniel, Gershenson, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168285/
https://www.ncbi.nlm.nih.gov/pubmed/37163105
http://dx.doi.org/10.1101/2023.04.24.537978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168285/
https://www.ncbi.nlm.nih.gov/pubmed/37163105
http://dx.doi.org/10.1101/2023.04.24.537978

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