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The conformational landscape of a serpin N-terminal subdomain facilitates folding and in-cell quality control
Many multi-domain proteins including the serpin family of serine protease inhibitors contain non-sequential domains composed of regions that are far apart in sequence. Because proteins are translated vectorially from N- to C-terminus, such domains pose a particular challenge: how to balance the conf...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168285/ https://www.ncbi.nlm.nih.gov/pubmed/37163105 http://dx.doi.org/10.1101/2023.04.24.537978 |