Genome-wide analysis of CRISPR perturbations indicates that enhancers act multiplicatively and without epistatic-like interactions

A single gene may be regulated by multiple enhancers, but how they work in concert to regulate transcription is poorly understood. Prior studies have mostly examined enhancers at single loci and have reached inconsistent conclusions about whether epistatic-like interactions exist between them. To an...

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Detalles Bibliográficos
Autores principales: Zhou, Jessica, Guruvayurappan, Karthik, Chen, Hsiuyi V., Chen, Aaron R., McVicker, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168320/
https://www.ncbi.nlm.nih.gov/pubmed/37163096
http://dx.doi.org/10.1101/2023.04.26.538501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168320/
https://www.ncbi.nlm.nih.gov/pubmed/37163096
http://dx.doi.org/10.1101/2023.04.26.538501

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