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Identification of a new Corin atrial natriuretic peptide-converting enzyme substrate: Agouti-signaling protein (ASIP)

Corin is a transmembrane tethered enzyme best known for processing the hormone atrial natriuretic peptide (ANP) in cardiomyocytes to control electrolyte balance and blood pressure. Loss of function mutations in Corin prevent ANP processing and lead to hypertension. Curiously, Corin loss of function...

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Detalles Bibliográficos
Autores principales: MacDonald, Bryan T., Elowe, Nadine H., Garvie, Colin W., Kaushik, Virendar K., Ellinor, Patrick T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168342/
https://www.ncbi.nlm.nih.gov/pubmed/37162877
http://dx.doi.org/10.1101/2023.04.26.538495