Improving the solubility of pseudo-hydrophobic Alzheimer’s Disease medicinal chemicals through co-crystal formulation

Natural products are ligands and potential inhibitors of Alzheimer’s disease (AD) tau. Dihydromyricetin (DHM) is a CNS active natural product. Despite having signature polyphenolic character, DHM is ostensibly hydrophobic owing to intermolecular hydrogen bonds that shield hydrophilic phenols. Our re...

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Detalles Bibliográficos
Autores principales: Tse, A, Janilkarn-Urena, I, Lin, J, Chang, X, Efthymiou, C, Idrissova, A, Zhang, M, Williams, CK, Magaki, S, Vinters, HV, Davies, DL, Gonen, T, Gukasyan, HJ, Seidler, PM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168350/
https://www.ncbi.nlm.nih.gov/pubmed/37162961
http://dx.doi.org/10.1101/2023.04.25.538327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168350/
https://www.ncbi.nlm.nih.gov/pubmed/37162961
http://dx.doi.org/10.1101/2023.04.25.538327

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